Netflix's latest Danish thriller, 'Secrets We Keep', has quickly become a sensation among viewers and critics alike, securing a spot in the top 10 most-watched shows on the platform shortly after its release. The series, known as 'Reservatet' in Denmark, has been praised for its gripping narrative and complex characters, drawing comparisons to the works of Harlan Coben and recent hits like 'Adolescence'. Its rapid ascent in popularity underscores the global appeal of Nordic noir and the streaming giant's ability to curate content that resonates across cultures.
The show's plot revolves around Cecilie, a high-powered executive and mother, who finds herself drawn into the investigation of a missing au pair in her affluent Copenhagen neighborhood. As she delves deeper, the facade of her perfect suburban life begins to crumble, revealing dark secrets and societal divides. The series has been lauded for its exploration of themes such as class, social norms, and the hidden dangers of the 'manosphere' culture among teenagers, making it a timely and thought-provoking watch.
Critics have been particularly effusive in their praise, with 'Secrets We Keep' achieving a rare 100% rating on Rotten Tomatoes. This unanimous acclaim highlights the show's quality and its ability to stand out in a crowded genre. The performances, especially by Marie Bach Hansen as Cecilie, have been singled out for their depth and nuance, contributing to the series' suspenseful and engaging atmosphere.
With its combination of mystery, social commentary, and high production values, 'Secrets We Keep' is poised to remain a topic of conversation among Netflix subscribers and critics for the foreseeable future. Its success not only cements Netflix's reputation as a home for compelling international content but also signals the enduring popularity of Nordic noir on the global stage.
Attached to nearly every human cell is an antenna-like structure known as the primary cilium, which senses the cell's environment and controls how it responds to signals from its surroundings. New research from the U.S. and Sweden has mapped and identified hundreds of proteins that comprise these structures, contributing new insights for future research into ciliary biology, disease mechanisms and potential therapies.
Publishing in the journal Cell, researchers from KTH Royal Institute of Technology and Stanford University used advanced imaging and antibody-based techniques to map proteins inside primary cilia across three types of human cells. They analyzed more than 128,000 individual cilia and identified 715 proteins that are located in different parts of the cilium responsible for sensing mechanical or chemical signals, such as hormones. These primary cilia are distinct from motile cilia, which are responsible for movement of fluids or cells.
Professor Emma Lundberg, a researcher in cellular and clinical proteomics at KTH Royal Institute of Technology, says the study also identified a possible gene behind various disorders linked to malfunctions of the cilium. These can lead to disorders affecting many parts of the body, from the brain and eyes to the kidneys and bones. In addition, the researchers discovered 91 proteins that had never before been linked to cilia.
The study expands the current understanding of cilia, casting them as highly adaptable and versatile processors of information, which tune their protein composition to suit the needs of the cell they belong to. "Cells seem to customize the protein composition of their cilia to have them perform specific sensing tasks," Lundberg says. "These newly-discovered ciliary proteins inspire many new hypotheses about their roles in cellular function and human health."