Inozyme Pharma, Inc. has reported encouraging interim data from its ENERGY 3 trial, showcasing INZ-701's potential to alter the disease trajectory in patients with ENPP1 Deficiency. The clinical-stage biopharmaceutical company highlighted sustained increases in phosphate levels alongside a favorable safety and immunogenicity profile, marking a significant step forward in addressing this rare disease.

The ENERGY 3 trial, which completed enrollment in January 2025, is on schedule to deliver topline data in the first quarter of 2026. Douglas A. Treco, Ph.D., CEO and Chairman of Inozyme Pharma, expressed optimism about the trial's progress, noting the absence of patient dropouts, dose adjustments, or discontinuations. This consistency across key metrics underscores the potential of INZ-701 to become the first approved therapy for ENPP1 Deficiency, a condition with significant unmet medical needs.

Adding to the company's momentum, Petra Duda, M.D., Ph.D., has been appointed as Chief Medical Officer. Her expertise is expected to bolster Inozyme Pharma's clinical development efforts as it advances INZ-701 through pivotal trials. The appointment comes at a critical juncture, with the company poised to make significant strides in rare disease therapeutics.

As Inozyme Pharma continues to navigate the clinical development landscape, the progress of the ENERGY 3 trial and the strategic addition to its leadership team underscore its commitment to innovation in rare disease treatment. With the anticipation of topline data in early 2026, the medical and investment communities are closely watching INZ-701's journey toward potential approval and its impact on patients with ENPP1 Deficiency.

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